A presentation, even in the most informal settings, should be seamless.
Like a good magician, “hide your wires” by saving your PowerPoint “Presentation” (.ppt) as a PowerPoint “Show” (.pps). This will open your presentation in slideshow mode.
A quicker way is to just manually change the extension on the file from .ppt to .pps. (Ignore PowerPoint’s warning about altering the file when you do this.)
In Keynote, select “Automatically play upon opening” in the Inspector: Document panel.
Presenting a PDF? Set the document properties to “Open in full screen mode.”